Neural tube defects
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You are here: Home » Medical Subject Notes , Pathology Notes » Neural tube defects
Anencephaly
1-5/1000 live births
Forebrain (and skin and skull overlying it) is gone and replaced with area cerebrovasculosa (which is blood vessels and glial cells)
Posterior fossa spared
Preconception folate deficiency is important risk factor
Encephalocele: protrusion of occipital or posterior fossa through the back of the head; it’s usually covered by skin
Spina bifida
Most common NTD
Vertebral column fails to fuse, creating a defect
Meningocele is protrusion of just the dura
Meningomyelocele is protrusion of dura and spinal cord; associated with motor weakness, paralysis, and urinary incontinence
Category: Medical Subject Notes , Pathology Notes
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