POST-INFECTIOUS GLOMERULONEPHRITIS (Robbins pp 949, )
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28.11.07
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You are here: Home » Pathology Notes » POST-INFECTIOUS GLOMERULONEPHRITIS (Robbins pp 949, )
- General: a.k.a: diffuse proliferative GN (i.e.: proliferation of glomerular cells).
- Causes: Nephritic syndrome
- Epidemiology:/At risk individuals: 6-10 year old children, 1-4 wks post-strep infection (usually Group A beta haemolytic strep).
- Clinical features / course: Nephritic syndrome. Caused by deposition of immune complexes in glomeruli. Antistreptolysin (antibodies) titre is high.
- Morphology: LM: hypercellularity due to infiltration of neutrophils/monocytes + proliferation of mesangial/endothelial cells. IF: IgG + C3 in basement membrane. EM: humps (immune complexes).
- Treatment: most recover, some progress ≫ chronic GN ≫ ESRF
Category: Pathology Notes
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