FOCAL & SEGMENTAL GLOMERULOSCLEROSIS – FSGS (Robbins pp 956,)
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28.11.07
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You are here: Home » Pathology Notes » FOCAL & SEGMENTAL GLOMERULOSCLEROSIS – FSGS (Robbins pp 956,)
General: focal & segmental just means, it affects only some glomeruli, that too – only a segment of it. Sclerosis = hardening. Causes: Nephrotic syndrome
Epidemology/At risk individuals: 10-15% of nephrotic syndrome in children + adults.
Clinical features/course: 1) non-selective proteinuria, 2) microhaematuria, 3) hypertension. Progress to chronic glomerulonephritis ≫ 50% go to ESRF.
Morphology: LM: Glomeruli: partially sclerotic, hyalinosis. EM: loss of podocyte processes + denudation of underlying GBM. IF: IgM + C3 in sclerotic areas.
Management: poor response to corticosteroids
Category: Pathology Notes
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