Iron acquisition mechanisms
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production of siderophores, which are low-MW compounds that chelate iron and compete with iron-binding proteins produced by the host
bacteria have special transport mechanisms to take up these Fe-bound siderophores back up into the bacteria
in case 3, this is the mechanism that E. coli uses to get iron from the host
direct uptake of iron from bound transferrin/lactoferrin
this is what Neisseria uses
these organisms grow on mucosal surfaces. lactoferrin is the main Fe-binding protein on mucosal surfaces
use of heme from tissue breakdown
Category: Microbiology Notes
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