Hypertrophic Cardiomyopathy

• symmetric septal hypertrophy
• idiopathic hypertrophic subaortic stenosis
• hypertrophic subaortic stenosis

• AD (50%)
• Inherited Sarcomeric mutations
• 1/3 caused by mutation of β myosin heavy chain. Also troponin and tropomyosin
• Most common reason for heart deaths in young athletes
• Young men

• Hypertrophy of all chamber walls, especially IV septum
• Casues diastolic failure (stiff ventricle can’t fill)Disoriented, tangled, hypertrophied fibers
• Causes LV outflow obstruction (30%), esp if asymmetric IV septum hypertrophy just below the aorta
• Causes ant leaflet of mitral valve to hit IV septum → thickening of endocardium on leaflet and septal wall
• Causes ↑ in pulm venous P and dilated LA
• Late stage fibrosis → CHF
• Harsh systolic ejection murmur
• Myocardial ischemia and ventricular arrythmia

Category: Pathology Notes