MEMBRANOPROLIFERATIVE GLOMERULONEPHRITIS (Robbins pp 958, Fig 21-23)

• General: a.k.a. mesangiocapillary GN. Causes: combines nephrotic/nephritic syndrome
• Epidemiology/At risk individuals: disease of all ages
• Clinical features / course: Two types present:
  
• Primary,
  
• Primary divided into two types based on microscopic features:
  
• 1) Type 1,
  
• 2) Type 2.
  
• Primary disease is caused by deposition of immune complexes in glomerulus + activation of alternate complement pathway.
• Secondary.
  
• Secondary disease is caused by systemic diseases.
  
• Clinical features: nephrotic / nephritic syndrome.
• Morphology: LM: Both types of primary disease show similar features: mesangial proliferation, leukocyte infiltration. EM: Type 1: subendothelial deposits + C3 + IgG, Type II: deposits within GBM + C3 in GMB.

Category: Pathology Notes