GOOD PASTURE SYNDROME (Robbins pp 739)
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26.11.07
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- General: Causes: Nephritic syndrome
- Epidemiology/At risk individuals: Males more affected, young age.
- Clinical features / course: There are antibodies made against basement membranes in kidney and these cross react with BM of lung. This causes inflammation ≫ injury. Nephrotic syndrome + pulmonary haemorrhage.
- Morphology: LM: proliferation within glomeruli +- crescents. IF: IgG + C3 deposits along GMB.
- Treatment: Plasma exchange: removes antibodies to basement membrane. GN improves, but poor prognosis anyhow.
Category: Pathology Notes
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