CRESCENTERIC GLOMERULONEPHRITIS (Robbins pp 951, Fig 21-17)

• General: a.k.a: rapidly progressive glomerulonephritis. This disorder can be caused by a number of causes, but there has to be a crescent shaped mass present in glomeruli to fit into this category.
• Epidemiology/At risk individuals:
• Clinical features/ course: Nephritic syndrome. Rapidly progresses to renal failure ≫death if left untreated.
  
• There are 3 types:
  
• Type I: anti-GBM disease (i.e.: Goodpasture),
  
• Type II: deposition of immune complexes in glomeruli (i.e.: acute proliferative GN, IgA nephropathy etc),
  
• Type III: no anti-GBM antibodies, no immune complexes but mediated by ANCA.
• Morphology: LM: characteristic crescent shaped mass of glomerular proliferation.
• Treatment: treat according to type of disease they have as this is a group of diseases. Crescenteric

Category: Pathology Notes