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Vitamin | Function | Deficiency | Excess |
A | Visual pigment (retinol) | Night blindness Dry skin | Arthralgia, HA, fatigue, skin changes, alopecia |
B1 thiamine | Enzyme cofactor | Beriberi (polyneuritis, cardiac path, and edema) Wernicke-Koraskoff | |
B2 riboflavin | Cofactor of oxidation / reduction; FAD | Cheilosis, angular stomatitis, corneal vascularization | |
B3 niacin | Redox rxns; NAD | Pellagra (diarrhea, dermatitis, dementia), beefy glossitis | |
B5 | CoA; fatty acid synthesis | Dermititis, enteritis, alopecia, adrenal insufficiency | |
B6 | Enzyme cofactor | Convulsions, hyperirritibility | |
Biotin | Cofactor of carboxylation | Dermatitis, enteritis | |
Folic acid | Synthesis of DNA / RNA | Macrocytic megaloblastic anemia, sprue | |
B12 | Cofactor | Macrocytic megaloblastic anemia, neurologic sx, glossitis | |
C | Hydroxylation of proline / lysine | Scurvy (swollen gums, bruising, anemia, ßhealing) | |
D | GI absorption of calcium | Rickets, Osteomalacia, tetany | loss of apetite; seen in Sarcoidosis |
E | Antioxidant (especially rbc) | | |
K | Synthesis of Factors II, VII, IX, X; proteins C & S | Neonatal hemorrhage, ÝPT, ÝPTT, normal bleed time | |
copper | Cofactor for; lysyl oxidase, superoxide dismutase, ferroxidase, tyrosinase. | Poor wound healing, dissecting anuerysm. | |
zinc | cofactor for; superoxide dismutase, alkaline phosphatase, thymidine kinase, alcohol dehydrogenase, collagenases - responsible for transforming scar from weak type III to strong type I collagen. | Poor wound healing. Erythematous pustules and scales resembling psoriasis around mouth genitalia anus feet elbows knees | |
Tags: polyneuritis, cardiac, edema, Arthralgia, HA, fatigue, skin changes, alopecia
Category: Biochemistry Notes
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