Top 20 Points on Dopaminergic and Serotinergic Neurotransmitters

1. Delay and Deniker first isolated dopamine receptors.
2. Carlsson and Lindquist first used ECT
3. Sakel is a name associated with insulin coma therapy
4. Yohimbine is an Alpha 2 noradrenergic receptor antagonist.
5. Noradrenaline is a precursor of dopamine
6. Dopamine is a precursor of nor adrenaline
7. Tetrabenazine causes depletion of dopamine.
8. Risperidone is a strong antagonist of the 5HT2A receptors
9. Second messengers are characteristic of ion-channel receptors.
10. D1 and D5 belong to same family
    
11. Glutamate is a NMDA antagonist
12. Memantine blocks NMDA receptors
13. Nicotinic receptors control cation channels
14. Heteroreceptors cause decrease neurotransmitter release through presynaptic mechanisms
15. Heteroreceptors can be ionotropic or metabotropic.
16. α₂ receptors are excitatory and use inositol phosphate as a second messenger
17. 5-HT3 receptors are linked to Na-Ion channels
18. All 5HT₁ and 5HT₂ receptors are G-protein coupled.
19. 5HT3 is an anion channel
20. Serotonin receptors are all metabotrophic

Category: Pharmacology Notes