INTRAVENOUS ANAESTHETICS - 3
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13.1.09
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You are here: Home » Pharmacology Notes » INTRAVENOUS ANAESTHETICS - 3
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CNS | Agent | Etomidate | Diazepam | Midazolam | Flumazenil |
| EEG | Like thio
| Resemble barbiturates Ceiling effect Can’t produce isoelectric | Resemble barbiturates Ceiling effect Can’t produce isoelectric |
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| CBF | ↓ 34% | ↓ | ↓ |
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| Autoregulation |
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| ICP | ↓ 50% |
| 0 |
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| CPP |
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| CMRO2 | ↓ 45% | ↓ (parallels CBF) | ↓ (parallels CBF) |
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| Protection |
| Pentobarb>midaz>diaz | Pentobarb>midaz>diaz |
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| Convulsant |
| Potent anticonvulsant | Potent anticonvulsant |
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| IOP |
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| SSEP |
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| Other | Movt 30% |
| Vasomotor response to CO2 preserved |
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| Mechanisms |
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CVS | CO | 0 |
| 0 |
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| BP | 0 | ↓ | ↓=thio > diazepam |
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| SVR | 0 |
| ↓ |
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| Barorec reflex |
| Impaired | impaired |
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| HR | 0 | ↑ | ↑ > diazepam |
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| Contractility | 0 |
| 0 |
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| Arrhythmias |
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| Mechanisms |
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Resp | Resp dep | + | Dose dependent | Dose dependent |
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| RR | ↑→apnoea |
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| TV |
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| Reflexes |
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| Bronchial m |
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| Other |
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| Mechanisms |
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| Hepatic | Blood flow |
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| Enzymes |
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| Renal | Blood flow |
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| Obste- trics | Uterine tone |
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| Placental T/F |
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| Skel muscle |
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| Relaxation (spinal interneurons) |
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SEs | Pain on inject | Pain |
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| Thrombophleb | Phlebitis | Venous irritatation |
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| Intra-art inject |
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| Other | Adrenal suppression PONV 30%
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| Resp depression | Anxiety, tremor | |
| Special | CIs |
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| Other |
| Tolerance & dependence | Tolerance & dependence |
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Category: Pharmacology Notes
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