Progressive supranuclear palsy
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Initially, vertical gaze is lost (progresses to all eye movements); also see disequilibrium, rigidity, and dementia
Onset in later adulthood, males 2X more often, death within 10 years
Widespread atrophy in the deep gray matter (globus pallidus, subthalamic nucleus, tectum, preiaqueductal gray matter, and dentate nucleus) with sparing of the cortex and formation of tangles (not flame-shaped, but round [called “globos”]) that may contain small amounts of tau protein (not the major component like the tangles of AD
Category: Pathology Notes
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