Antiepileptic & Antiseizure drugs

Valproic Acid

• Antiepileptic

• Can Produce Liver problems

• Associated with prolonged bleeding

Falbutol (Falamate)

• Aplastic anemia, and severe hepatitis

Gabapentin

• Anticonvulsant / Antiseizure (epilepsy)

• GABA mimetic

• Indicated in Tx of Neuropathic pain such as postherpatic and diabetic neuropathy

Phenytoin(dilantin)

• lowers neuronal firing

• antiarrhythmic

• lowers cellular Na+ influx

• Gingival hyperplasia

Carbemazopine (Tegretol)

• Agent of choice in Tx of trigeminal neuralgia

• Must monitor blood due to risk of Leukopenia, and agranulocytosis

Baclofen

• GABA-B agonist

• Antispasmotic

Phenobarbitol

• For tx of Grand Mal seizure

• Anticonvulsant and for Tx of trigeminal neuralgia

• Inactivated by oxidation

• Problems similar to all barbiturates.

• Sedation and abuse

• Induces P450**