Toxic shock syndrome toxin-1 (TSST-1)
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You are here: Home » Microbiology Notes » Toxic shock syndrome toxin-1 (TSST-1)
it is a superantigen, which is a molecule that facilitates the interaction of APCs with T cells
instead of this being an antigen-specific interaction (where processed MHC particle is presented on MHC and this is presented to TH cell), superantigen mediates a nonspecific interaction between any T cell and any APC
this leads to clonal expansion of any T cell that the superantigen helps activate
this leads to the production of a variety of cytokines and, ultimately, shock
Superantigens of Staph. aureus
Staphylococcal enterotoxins are associated with food poisoning too
Category: Microbiology Notes
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