Neutrophils and macrophages

on 7.9.08 with 0 comments



Phagocytosis

  • phagosome fuses with lysosome that contains enzymes

  • this forms a phagolysosome

  • bacteria is killed

  • residue is released by exocytosis


Oxygen-independent microbial killing

  • mediated by a variety of factors


Oxidative burst killing in the phagolysosome (oxygen-dependent)

  • key enzyme is NADPH oxidase, which generates superoxide anion (O2-) that can then be processed into a variety of toxic chemicals


Chronic granulomatous disease (CGD)

  • caused by NADPH oxidase mutation; there is impaired oxidative burst

  • patients have recurrent Staph. infections

  • the life expectancy is much reduced

Category: Microbiology Notes

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