How do proinflammatory cytokines (IL-1, IL-6, TNF-α) help support innate immune defense?
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You are here: Home » Microbiology Notes » How do proinflammatory cytokines (IL-1, IL-6, TNF-α) help support innate immune defense?
they go to the liver and stimulate production of acute-phase proteins, leading to activation of complement cascade and opsonization
stimulate bone marrow endothelium, leading to neutrophil mobilization
increase body temperature via effects in the hypothalamus
in fat and muscle, mobilize protein and energy
TNF-α in particular stimulates dendritic cells to migrate to lymph nodes
Secreted pattern recognition proteins also contribute to innate immunity
opsonins bind to microbes; these opsonized microbes are phagocytosed and killed
Category: Microbiology Notes
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