Emphysema facts
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it is a common disease
centriacinar >> panacinar
comprise 95% of emphysema; clear-cut association with heavy smoking
hypothesis of pathogenesis: imbalance between proteases and anti-proteases
smoking stimulates elastase secretion and lowers antielastase (α1-antitrypsin) secretion. this leads to elastic damage
this can also happen in people with congenital α1-antitrypsin deficiency
Category: Pathology Notes
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