Mediators of inflammation

on 27.8.08 with 0 comments



  • vasodilation

    • prostaglandins

    • nitric oxide

  • increased vascular permeability: both preformed molecules and not

  • chemotaxis

    • best chemotactic agent: C5a, which is made before LTB4

    • leukotriene B4

    • many bacterial products

    • chemokines, among the best of which is IL-8

  • fever

    • IL-1, IL-6, TNF-α

    • prostaglandins, the synthesis of which are inhibited by aspirin

  • pain

    • prostaglandins

    • bradykinin

  • tissue damage

    • lysosomal enzymes from neutrophils that burst open and die

    • physical mediators, including knife, club, falling down, gravel, sandpaper

Category: Pathology Notes

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