Effects of ANS Neurotransmitters on effector Organ systems

on 20.1.08 with 0 comments



Eye



Adrenergic

Effects


Cholinergic


Iris: Radial Muscle

N.E., alpha-1 receptor

contraction (mydriasis)

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Iris: Sphincter muscle

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contraction (miosis)

Ciliary Muscle

N.E., beta2 receptor

relaxation (far vision)

contraction (near vision)

Heart




Adrenergic

Effects


Cholinergic



Sino-atrial (SA) Node

beta1; beta2

increase rate

decrease rate (vagal)

Atrial muscle

beta1, beta2

increased: contractility, conduction velocity

decreased: contractility, action potential duration

Atrio-ventricular (AV) node

beta1, beta2

increased: automaticity*, conduction velocity

decreased conduction velocity; AV block

His-Purkinje System

beta1, beta2

increased: automaticity, conduction velocity

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Ventricles

beta1, beta2

increased: contractility, conduction velocity, automaticity, ectopic pacemaker

small decrease in contractility

Skeletal Muscle

Adrenergic Effects



Cholinergic


Skeletal Muscle

beta2

increased: contractility;
glycogenolysis; potassium uptake

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Liver


Adrenergic Effects



Cholinergic



Liver

alpha1;beta 2

glycogenolysis and gluconeogenesis

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Category: Pharmacology Notes

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