Classification of Anti-Cancer Agents

1. Alkylating Agents
1. Nitrogen mustards: Mechlorethamine,Melpala,Cyclophosphamide,Chlorambucil
2. Nitrosoureas: Carmustine,Lomustine
3. Alkylsulfonates: Busulphan
4. Ethyleneimines: Thiotepa
5. Triazene: Dacarbazine
6. Methyl Hydrazines: Procarbazine
7. Platinum Coordination complexes: Cisplatin,Carboplatin,Oxaliplatin
2. Antimetabolites
1. Folate Antagonists: Methotrexate
2. Purine antagonists: 6-Mercaptopurine (6-mp),6-thioguanine (6-TG)
3. Pyrimidine antagonists: 5-Fluorouracil (5-FU),Cytarabibe,Capecitabine
3. Natural Products
1. Plant Products
1. Vinca Alkaloids: Vincristine,Vinblatine
2. Taxanes: Paclitaxel,Docetaxel
3. Epipodophyllotoxins: Etoposide,Teniposide
4. Camptothecins: Topotecan,Irinotecan
2. Microorganism Products
1. Antibiotics: Dactinomycin,Doxorubicin,Daunorubicin,Bleomycin,Mitomycin C, Mitoxantrone
2. Enzymes: L-Asparaginase
4. Miscellaneous
1. Hydroxyurea
2. Imatinib Mesylate
3. Rituximab
   
5. Hormones and Antagonists:
1. Corticosteroids: Prednisone,Dexamethasone
2. Estrogens:Ethinyloestradiol
3. Antiestrogens: Tamoxifen
4. Progestin: Hydroxyprogesterone caproate
5. Androgen: Testosterone propionate
6. Antiandrogen: Flutamide
7. Aromatase inhibitor: Letrozole
8. 5-alpha reductase inhibitor: Finasteride
9. GnRH Analogue: Leuprolide

S-Phase specific Agents: Methorexate,6-mp,hydroxyurea,Cytarabine

M-phase Specific Agents: Vincristine,vinblastine,paclitaxel,docitaxel

Nonspecific: Alkylating agents, Antitumor antibiotics .

Category: Pharmacology Notes