Drugs Used In Tuberculosis - Pyrazinamide
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19.1.08
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- First line anti tubercular agent
- Active against intracellular bacilli in acidic pH
Mechanism of Action
- Like Isoniazid it inhibits mycolic acid biosynthesis but through a different mechanism.
- It is tuberculocidal
Pharmacokinetics
- Orally administered and well absorbed from the gastrointestinal tract
- Widely distributed across all the body cavities
- Attains very high concentrations in the CSF and is very important agent in Tubercular meningitis.
- Metabolised in the liver and excreted in urine.
Adverse Effects
- Hepatitis
- Interferes with the excretion of Uric acid - Hyperuricemia
- May precipitate acute attacks of gout
Category: Pharmacology Notes
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