DIABETES MELLITUS GLOMERULOSCLEROSIS (Robbins 966, Fig 21-32)
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You are here: Home » Pathology Notes » DIABETES MELLITUS GLOMERULOSCLEROSIS (Robbins 966, Fig 21-32)
- General: Causes: ESRF.
- Epidemiology/At risk individuals: related to diabetes (i.e.: obesity etc).
- Clinical features / course: Proteinuria.
- Two main mechanisms:
- GBM thickening due to hyperglycaemia/insulin deficiency,
- mesangial proliferation. Patients go to ESRF.
- Morphology: LM: diffuse glomerulosclerosis (i.e: mesangial proliferation), intercapillaru glomerulosis (Kimmelstiel-Wilson nodules), vascular hyalinoses. EM: GBM thickening.
- Treatment: treat underlying diabetes.
Category: Pathology Notes
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