Role of the serotonin 5-HT2A receptor in schizophrenia and the actions of atypical antipsychotics.

on 17.9.07 with 0 comments




  1. Evidence for down-regulated 5-HT2A receptors in frontal cortex of schizophrenic patients.

  2. Evidence for up-regulation of the 5-HT2A receptor by antipsychotic drugs.

  3. Evidence for cortical 5-HT2A receptor regulation of dopaminergic function.

  4. Inverse agonism at the 5-HT2A receptor as a mechanistic explanation for antipsychotic action.

Category: Pharmacology Notes

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