IgA NEPHROPATHY (Robbins pp 961,)
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28.11.07
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You are here: Home » Pathology Notes » IgA NEPHROPATHY (Robbins pp 961,)
- General: a.k.a Berger Disease. Causes: Nephrotic syndrome
- Epidemiology/At risk individuals: Most common type of GN worldwide, occurs 1-2 days after URTI/GIT infections in patients
- Clinical features / course: There is an acquired or genetic defect in regulating production of IgA antibodies. After URTI / GIT infection, too much IgA is produced ≫ forms immune complexes trapped in mesangium ≫ elicit alternate complement pathway ≫ injury. Proteinuria + haematuria (Nephrotic syndrome). Progress to ESRF in 25-50% of patients.
- Morphology: LM: mesangial proliferation, matrix deposition. IF: IgA in mesangium + C3.
- Treatment: none.
Category: Pathology Notes
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