Antimetabolites
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Flucytosine
Mechanism of action: selectively converted by fungi to active metabolites
inhibits fungal RNA and DNA synthesis
Absorption: well absorbed; used orally (only)
Uses: only in combination with
- amphotericin B for cryptococcal meningitis
- itraconazole for blastomycoses
[high incidence of resistance as well as toxicity reduced via use in drug combinations]
Adverse effects: (narrow therapeutic window)
- results from fluorouracil = major metabolite
- inflamed bowel (enterocolitis)
- bone marrow toxicity
- possible liver toxicity
Tags: Flucytosine, amphotericin B
Category: Pharmacology Notes
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