Cytoskeleton Agent

Griseofulvin

Mechanism of action: proposed to inhibit microtubules

blocks fungal mitosis, therefore is fungistatic

also binds keratin

Absorption: poor - very insoluble

orally administered in a microcrystalline form

(improved when taken with fatty foods)

Uses:

systemic uses for dermatophytosis (eg. skin and, esp. nail infections, though for the latter terbinafine is preferred),

requiring extended treatments [after or sometimes with treatment with triazoles]

[also highly effective against Athlete’s foot and ringworm]

Adverse effects: (low incidence)

- allergic syndrome (like serum sickness: fatigue.. - rare)

- hepatitis

- drug interaction with warfarin or phenobarbital

Category: Pharmacology Notes