Neurotransmitters found in the nervous system
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You are here: Home » Pharmacology Notes » Neurotransmitters found in the nervous system
Acetylcholine (Ach): Widely distributed in almost all regions of CNS. Predominantly in cerebral cortex, ascending reticular system, cerebellum and spinal cord. Both excitatory and inhibitory in nature. Central effects can be blocked by atropine
Noradrenalin (NA): High concentration in the hypothalamus, limbic system and reticular formation in the brain stem. Both excitation and inhibition in the brain stem.
Dopamine (DA): Mainly in the basal ganglia, to some extent in the median eminence of hypothalamus, Adenohypophysis and frontal cortex. Predominantly inhibitory action. Deficiency causes extrapyramidal disturbances
5-Hydroxytryptamine (5-HT): Similar to noradrenaline. Extends into the cerebral cortex, Raphe nucleus and hippocampal areas. Both excitatory and inhibitory effects
Histamine: Distribution similar to Noradrenaline and 5HT but irregular. Mainly inhibitory effects. Functions uncertain
Amino Acids Neurotransmitters
L-glutamic acid and aspartic acid: Widely distributed in CNS and spinal cord. Excitant effects (EAA).
Gamma-aminobutyric acid (GABA), glycine: GABA in CNS; glycine mainly in the spinal cord and brain stem. Inhibitory effects in brain and the spinal cord
Category: Pharmacology Notes
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