ANTICHOLINERGICS
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16.3.06
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You are here: Home » Pharmacology Notes » ANTICHOLINERGICS
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Drug
| Agent | Atropine | Glycopyrrolate | Hyoscine |
| Class | Alkaloid Tertiary amine | Semisynthetic Quaternary amine | Alkaloid Tertiary amine | |
| Structure
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| Presentation
| 1200mcg/1ml | 400mcg/2ml | 0.4mg/1ml 20mg/1ml | |
|
Admin | Use | Reversal NDMBs | Reversal NDMBs | Preop med Anti-sialogogue Sedation Motion sickness |
| Dose (mg) | 15-20mcg/kg | 10mcg/kg | Post auricular patch 5mcg/hr for 72hrs 0.4mg sc/im/iv antisialogue 20mg im/iv antispasmodic | |
| Onset (min) | 1min | 2-3min |
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| Duration (min) | 30-50min | 30-60min |
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P/kin | Vd (L/kg) |
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| CL (ml/kg/min) | | >atro |
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| Renal | 20% | 80% | 1% | |
| Hepatic | 80% hydrolysis | 20% bile | Mostly metabolised | |
| t1/2 (min) | 2.3hrs | 1.25hr |
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| P/dyn | Sedation | + | 0 | +++ |
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| Antisialogogue | + | ++ | +++ |
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| ↑ heart rate | +++ | ++ | + |
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| Relax smooth muscle | ++ | ++ | + |
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| Mydriasis / Cycloplegia | + | 0 | +++ |
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| Anti-nausea | + | 0 | +++ |
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| ↑ gastric acid secn | + | + | + |
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| Altered fetal HR | 0 | 0 | ? |
Low dose high dose:
1. Salivary/bronchial secretions
2. Heart, eyes
3. GIT, GU
4. Gastric
Category: Pharmacology Notes
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