Inherited Disorders of RBC morphology
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14.12.09
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-ovalocyte shapes- oval shaped
-spiculated red cells- looking like spiny protrusion
-sickled shape
-all of these abnormal shapes will shorten the survival of the RBC and lead to anemias.
There is a class of cytosekeletal proteins beneath the cytoplasmic membrane of the RBC
-function to contribute to the appropriate shape of the cell, when one is structurally modified or absent because of mutation there will be an aberrant shape that will lead to anemia due to premature lysis. The lysis comes about to them being trapped in the spleen because of their aberrant shape, they will then be phagocytosed.
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Category: Anemia , Biology , Cell , Cell membrane , Kids and Teens , Medical Subject Notes , Phagocytosis , Red blood cell , Spleen
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