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Pseudo-icterus (hypercarotenaemia, mepacrine therapy) should be differentiated from true icterus (jaundice). Check the colour of sclerae and the case history. Eating an excessive amount of carrots or papaya is a frequent cause of deep yellow-orange skin, but with normal sclerae.
Patients with Gilbert syndrome could be icteric as a result of intercurrent infections. An increase in unconjugated bilirubin is found.
A prehepatic, hepatic or post-hepatic cause is often differentiated in icterus. Mixed causes frequently occur. Icterus occurs with liver amoebiasis and schistosomiasis only very late, in the pre-terminal stage.
Category: Medical Subject Notes , Medicine Notes
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