Dysplastic maturational changes (megaloblastoid) of myelodysplastic syndromes
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You are here: Home » Medical Subject Notes , Pathology Notes » Dysplastic maturational changes (megaloblastoid) of myelodysplastic syndromes
Megaloblastoid changes in the absence of B12 or folate deficiency
These are macrocytic anemias that may or may not be seen with neutropenia, hypogranularity, thrombocytopenia, and/or monocytosis
The marrow is hypercellular and may have increased amounts of ringed sideroblasts
Many patients have chromosomal abnormalities and all are at an increased risk of infection and acute leukemia
This is a diagnosis of exclusion…always try to treat for B12 and/or folate deficiency first, and then move onto looking for this if there is no improvement
Category: Medical Subject Notes , Pathology Notes
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