Causes, lab diagnosis, and clinical significance of the anemia of “chronic disease.”
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You are here: Home » Medical Subject Notes , Pathology Notes » Causes, lab diagnosis, and clinical significance of the anemia of “chronic disease.”
Seen with chronic liver disease, inflammation, infection, autoimmune d/o, etc
Usually normochromic and normocytic, but may be microcytic and hypochromic, and thus easily confused with Fe-deficiency
Serum [Fe] is low, but TIBC is reduced
Serum [ferritin] and bone marrow stores are usually increased due to defective Fe reutilization
Reversible with control of underlying disease
| Parameter
|
Iron Deficiency
|
Chronic Illness
|
| Serum Fe
| Decreased
| Decreased (normal in thalassemias)
|
| Transferrin
| Increased
| Decreased (what’s there isn’t functionally normal)
|
| Transferrin Saturation (%)
| Decreased
| Decreased/Normal (Fe won’t bind)
|
| TIBC of Transferrin
| Increased
| Decreased/Normal (due to dysfunctional transferrin)
|
| Ferritin
| Decreased (unless there’s inflammation)
| Normal/Increased (depends on how much useless Fe is trapped in the marrow)
|
| Free Erythrocyte Protoporphyrin
| Increased (no Fe to complex it and make Hb)
| Normal
|
| Anisocytosis (RDW)
| Increased
| Normal
|
Category: Medical Subject Notes , Pathology Notes
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