Some notes about clotting factor abnormalities
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All of these will show bleeding (not petechial bleeding as is seen with platelet defects, but as large ecchymoses or hematomas after a minor injury) with normal platelet number and function
The intrinsic pathway is measured by aPTT, the extrinsic by the PT; both measure the formation of fibrin (thus, problems with the common pathway will show prolongation of both PT and aPTT)
Factor XIII polymerizes fibrin, thus problems with factor XIII will show lots of bleeding, with normal platelet number and function, PT, aPTT, and thrombin time
Bleeding into GI and GU tracts and into weight-bearing joints is common
Category: Medical Subject Notes , Pathology Notes
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