Benign and malignant tumors of thymic epithelium (thymomas)

on 9.2.09 with 0 comments



  • Thymomas are tumors of thymic epithelial cells with a variable component of reactive thymic T cells

  • Benign: encapsulated with no significant cytologic atypia

  • Malignant: invasive and/or cytologically malignant; capable of local invasion and/or metastasis

  • Paraneoplastic syndromes

    • These are how the thymomas will present

    • Myasthenia gravis – weakness

    • Grave’s disease – thyroid enlargement and exophthalmos

    • Acquired hypogammaglobulinemia – T cell response causes decrease of Ig production

    • Pure RBC aplasia

    • Pernicious anemia

    • Dermatomyositis/polymyositis

    • Cushing syndrome

Category: Medical Subject Notes , Pathology Notes

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