3 major etiologies of neutropenia

on 27.2.09 with 0 comments



  • Inadequate or ineffective granulopoiesis from

    • Aplastic anemia

    • Infiltrative marrow d/o like mets

    • Myelosuppressive drugs (including chemo)

    • Idiosyncratic drug reactions

    • Megaloblastic anemia

    • Myelodysplastic syndromes

    • Congenital neutropenias such as Kostmann syndrome

  • Accelerated neutrophil removal and destruction

    • Immunologic d/o such as Felty’s syndrome (rheumatoid arthritis with splenomegaly [due to sequestration of neutrophils in there], neutropenia, and leg ulcers)

    • Hypersplenism with splenic sequestration

  • Decreased production and increased destruction

    • Drug effects including sulfas and chloramphenicol

    • Viral infections

    • Overwhelming sepsis

Category: Medical Subject Notes , Pathology Notes

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