Urate nephropathy

Name the conditions that are associated with acute uric acid nephropathy?

• Leukemia / Lymphoma patients undergoing chemotherapy

Know the cause of chronic urate nephropathy and the morphology of urate crystal

• Occurs during protracted periods of hyperuricemia

• Deposition of crystals occurs in the distal tubules and collecting ducts

• Form birefringent, needle-like crystals present either in the tubular lumina or interstitium

• The urates induce a tophus, often surrounded by foreign body giant cells, other mononuclear cells, and a fibrotic reaction

What are the causes of uric acid stone?

• Stones are found in 22% of patients w/ gout

• Stones found in 42% of those w/ secondary hyperuricemia

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Category: Pathology Notes