RECEPTOR OCCUPATION CURVES
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At the 50% mark, half of the receptors are occupied. At this point Keq[D] = 1. If you know Keq, take 1/Keq and this tells you what dose will occupy half the receptors. We thus define 1/Keq as the dissociation constant, Kd. So when [D] = Kd, half the receptors are occupied. This means that when the drug binds strongly, the concentration of drug required to occupy the receptors is low. If it binds weakly then it takes a lot of drugs to occupy the receptors. The dose-response curve relates this .
The value of [D] that causes half the receptors to be occupied is sometimes called ED50 (effective dose that produces 50% of the maximal response). ED50 = Kd
Category: Pharmacology Notes
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