Equilibrium constant
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14.1.09
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Keq = [DR]/[D][R]
= drug-receptor association constant, binding constant, or affinity constant.
Keq tells how strongly the drug binds to a receptor.
[R]total = sum of both bound and unbound receptors = [DR] + [R]
([DR] and [R] can both change, but [R]total stays the same)
Now we can do some manipulation… how does [DR] change as we add more drug?
This will produce the dose-response curve (shown on page 2 of handout)
First, write equilibrium constant as: [DR] = Keq [D][R]
Then define [R] as: [R] = [R]total – [DR]
…and solve for [DR]
what you get is: [DR]/[R]total = Keq[D]/(1 + Keq[D])
Category: Pharmacology Notes
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