Neurosyphilis
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Meningovascular
Most common form
See plasma cells in the meninges
Special stains will show spirochetes
Parenchymal (gummas) – more of a granulomatous reaction
General paresis
Spirochetes invade the brain (and can be seen with special stains) and cause gliosis and other reactive changes
Fe deposits are common and there is a progressive neuronal loss
Tabes dorsalis
Looks similar to vacuolar myelopathy of AIDS
Involves posterior columns of the spinal cord
Will not see spirochetes with special stain
Present with sensory disturbances, shooting pains, loss of proprioception and ataxia
Category: Pathology Notes
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