Nephrotic Syndrome (NS) vs. Nephritic Syndrome

on 12.1.09 with 0 comments





Nephrotic syndrome

Nephritic syndrome

Proteinuria

>3-3.5g/dy (massive)

<3.0g/dy

Onset

insidious

abrupt

Renal Fn

Initially normal

Present w/  BUN & creatinine

hematuria

sometimes seen

often


  • Nephrotic syndrome  Massive proteinuria  caused by permeability & accomp’d by hypoalbuminemia, edema, hyperlipidemia, & lipiduria

  • Etiology of nephrotic syndrome 

    • 33% of adults & 10% of kids  caused by systemic dz’s (DM [most common cause], SLE, & amyloidosis)

    • 66% of adults & 90% of kids  is 2 to 1 glomerular disease such as MCD, MN, or MPGN

    • Other assoc’d dz’s 

      • Hodgkin’s disease  assoc’d w/ MCD

      • Breast, Lung & GI cancers  assoc’d w/ MN [most common tubular dz assoc’d w/ malignancy]

      • NOTE: if pt >45 yo & NS  think malignancy

      • 5% of PSGN can have NS

      • IgA nephropathy can have

Category: Nephrology Notes

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