Nephritic Syndrome

Know the urinary findings, renal functional change, plasma renin and aldosterone and clinical presentation of nephritic syndrome

• Urinary findings

• Hematuria - > 5 RBC/hpf
• Proteinuria – usually > 500mg, but <>
• Occasional RBC casts

• Renal functional changes

• Decreased GFR due to:
• Development of glomerular intracapillary thrombosis
• Acute tubular necrosis (secondary to ischemia)
• Tubular obstruction by casts
• Compression of glomerular tufts
• Plasma rennin/aldosterone levels are reduced due to impaired excretion of Na and water

• Clinical Presentation

• Hypertension – due to increased volume
• Edema – due to increased volume and often occurs in nondependent areas

Category: Pathology Notes