Immune Mechanisms and the Glomerular Response to Injury
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Know the immunofluorescent pattern in anti-GBM and immune complex disease in glomerulonephritis (GN)
- Anti-GBM staining produces a linear staining pattern along the capillary walls
- Immune complex disease produces granular deposits of Ig and complement within the mesangium, subendothelial surface, or subepithelial surface.
Know the pathogenesis of glomerular lesions in immune complex GN
- Immune complex deposits at subendothelial or mesangial sites
- Passive glomerular trapping of preformed immune complexes from circulation
- Form locally in situ - Antigens are trapped and later free Antibodies are trapped and bind
Category: Pathology Notes
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