MUSCLE RELAXANTS
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Drug | Agent | Vecuronium | Rocuronium | Atracurium | Cisatracurium |
| Trade Name | Norcuron | Esmeron | Tracrium | Nimbex | |
| Class | Monoquaternary aminosteroid | Monoquaternary aminosteroid | Bisquaternary benzyl isoquinolinium ester | Bisquaternary benzyl isoquinolinium ester | |
| Structure
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| Formulation
| Lyophilised powder (unstable in soln) 4mg/2ml or 10mg/5ml pH 4.0 | 50mg/5ml, 100mg/10ml pH 4.0 store @ 2-8C out of light | 25mg/2.5ml or 50mg/5ml pH 3.5 ( degradation) store @ 2-8C, out of light room temppotency 5%/30days | 5mg/2.5ml or 10mg/5ml store @ 3-8C away from light | |
| Isomers | Nil |
| 10 isomers | Cis-cis, 15% of atracurium (4-5 potent) | |
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Admin | ED95 | 0.05mg/kg | 0.3mg/kg | 0.2mg/kg | 0.05mg/kg |
| Intub dose (mg) | 0.1mg/kg | 0.6-1.0mg/kg | 03-0.5mg/kg | 0.15mg/kg | |
| Rpt dose | 0.03mg/kg | 0.15mg/kg | 0.1mg/kg | 0.03mg/kg | |
| Infusion | 1-2mcg/kg/min | 9-12mcg/kg/min | 4-12mcg/kg/min | 1-2mcg/kg/min | |
| Onset (sec) | 180sec | <60sec> | 110 sec | 140sec | |
| Duration (min) | 30min | 30min | 40min | 40min | |
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P/kin | Vdss (L/kg) | 0.2 | 0.2 | 0.2 | 0.2 |
| CL(ml/kg/min) | 5 | 5 | 3 | 4 | |
| Hepatic metab | 55% (active) | No metabolism |
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| Renal excretion | 25% | 10% | 10-40% | 20% | |
| Biliary excr | 20% | 70% |
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| Other elim |
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| Plasma esterase + Hoffmann 60-90% Laudanosine (seizures) | Hoffmann deg 80% Laudanosine (seizures) | |
| Temp | Yes | Yes | Slowed | Slowed | |
| pH | Enhance | No | Slowed | Slowed | |
| Renal func | Prolonged | No | No | No | |
| Hepatic func | Yes | Yes | No | No | |
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P/dyn | His release | 0 | (+) | ++ | 0 |
| Cardiac mus | 0 | (+) | 0 | 0 | |
| Gglia mus |
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| Other |
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Category: Pharmacology Notes
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