MUSCLE RELAXANTS - 2

Drug

Agent

Suxamethonium

Pancuromium

Mivacurium

Trade Name

SCh Cl for injection

Pavulon

Mivacurium for injection

Class

Dicholine ester of succinic acid

Bisquaternary aminosteroid

Bisquaternary benzyl isoquinolinium ester

Structure

Formulation

100mg/2ml SCh Cl

pH 3.0-5.0

store @ 2-8C

4mg/2ml panc Br

pH 4.0

20mg/10ml

Isomers

Nil

Trans-trans 60% 1

Cis-trans 30% 1

Cis-cis 10% 0.1

Admin

ED₉₅

0.07mg/kg

0.08mg/kg

Intub dose (mg)

1.0-1.5mg/kg

0.1mg/kg

0.15mg/kg

Rpt dose (mg)

0.03mg/kg

0.05mg/kg

Infusion

3-15mcg/kg/min

Onset (sec)

<30sec

3-5min

180sec

Duration (min)

10min

45-60min

15min

P/kin

V_dss (L/kg)

0.2

0.2

CL(ml/kg/min)

2

5

Hepatic metab

40%

Renal excretion

<10%

50%

7%

Biliary excr

Other elim

BchEsterase (80% pre)

BChEsterase 93%

Temp

pH

Renal func

Yes

No

Hepatic func

Yes

P/dyn

His release

+

<1%>95)

Cardiac mus

Stimbrady, AV block

vagolyticHR

0

Gglia mus

Stim  VEB, VF

0

Other

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