Latex allergy
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14.1.09
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- type I responses mediated by IgE Ab are fatal (less common) IgE mediated cutaneous, respiratory & systemic allergic rxns.
- Onset is 20 – 60 min after exposure, cause hypotension (most common sign), rash (not always seen) & bronchospasm.
Tx: avoidance of latex materials, ROUTINE PREOPERATIVE H1 & H2 BLOCKERS & STEROIDS ARE NO LONGER RECOMMENDED!!
Primary tx: stop admin of latex, maintain airway w/ 100% O2, discontinue all anesthetic agents, restore intravascular volume (2-4 L crystalloid). Start >2 large bore IV’s
Pharmacological cornerstone of tx is EPHINEPHRINE! Start w/ does of 10ug or 0.1 ug/kg.
Secondary tx: corticosteroids, antihistamines (Benedryl), catecholamine infusions, aminophylline.
Category: Pharmacology Notes
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