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GRADED RESPONSE CURVE: a continually increasing response of a single individual as response to increasing dose.
QUANTAL RESPONSE CURVE: amount of drug required to produce the same discreet response of different individuals, generally expressed as the number of individuals responding vs. the log dose.
DOSE-RESPONSE CURVE: See graded response curve (handout fig. 2)
POPULATION-RESPONSE CURVE: See quantal response curve (handout fig. 6)
ED50: median effective dose, usually the dose required to produce therapeutic response in 50% of the population.
ED10, ED90, etc.: dose required to produce a given effect (usually therapeutic response) in 10% or 90%, etc. of the population, respectively.
LD50: median lethal dose to kill 50% of the population.
THERAPEUTIC INDEX: LD50/ED50, we’d like this to be greater than 10, for a safe drug.
CERTAIN SAFETY FACTOR: LD1/ED99, we’d like this to be greater than 1, for a safe drug.
Category: Pharmacology Notes
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