Fibrinolytic Drugs

on 13.1.09 with 0 comments




t-PA (tissue plasmin activator), Urokinase, and streptokinase

  • Cleave plasminogen into plasmin, which in turn attacks fibrin, fibrinogen and factors V and VI.

  • Therapeutic effect is due to dissolution of Fibrin clots

  • Use for treatment of acute thrombolytic and embolytic events.

  • Must be administered parenterally

  • Risk of hemorrhage

  • Streptokinase is highly immunogenic and cannot be used repeatedly


Category: Pharmacology Notes

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