Cholinesterase inhibitors
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ACTHase at synapses throughout the nervous system
Plasma cholinesterase in noneural sites like plasma
Two types reversible and irreversible
Reversible: Competitive inhibitor (edrophonium) binds to substrate binding domain
Irreversible: phosphorylate the serine in the substrate-binding domain of ACTHase; therefore called organophosphorous cholinesterase inhibitors
Category: Pharmacology Notes
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