Essential Mixed Cryoglobulinemia (EMC)

on 11.12.08 with 0 comments



  1. Know the age and gender of patients with essential mixed cryoglobulinemia

  • Middle-age and female associations

  1. Know the systemic symptoms associated with essential mixed cryoglobulinemia

  • Dependent vascular purpura

  • Raynaud’s phenomenon

  • Arthralgias

  • Weakness

  1. Know the LM, IF, and EM findings

  • Diffuse, proliferative, and exudative GN, sometimes accompanied by vasculitis

  • Large PAS+ proteinaceous deposits present in capillaries

  • Subendothelial capillary deposits composed predominantly of IgG, IgM, and lesser amounts of C3 and fibrin

Category: Pathology Notes

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