Toll-like receptors
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You are here: Home » Microbiology Notes » Toll-like receptors
mammals have receptors with significant homology to Drosophila Toll receptors
the downstream signalers of TLRs lead to JNK and NF-κB
they instruct the adaptive response
unfortunately, if there is overwhelming bacterial infection, this can lead to septic shock
Peptidoglycan activates both TLR and NOD
Some key steps in TLR signaling via NF-κB
TLR has extracellular domain
it binds to microbial-specific antigens such as LPS
it recruits an adaptor protein, one of which is MyD88
this starts a signaling cascade. at the end of the cascade, Iκk phosphorylates IκB
phosphorylated IκB is degraded, releasing NF-κB to migrate into the nucleus and regulate gene transcription
Category: Microbiology Notes
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